Cyclin-dependent kinase 5 (Cdk5) regulates dopamine neurotransmission and has been suggested to serve as a homeostatic target of chronic psychostimulant exposure. To study the role of Cdk5 in the modulation of the cellular and behavioral effects of psychoactive drugs of abuse… read more
Studies have shown that cyclin dependent kinase 5 (Cdk5) plays a key role in the apoptosis of mature neurons. Our recent findings suggest that Cdk5 functions in the nucleus to regulate apoptosis. We propose in the present application to …
Journal Of Cell Science; 07/01/2007 (AN 17591690) MEDLINE with Full Text.
A team of Japanese scientists led by Toshio Ohshima, at the RIKEN Brain Science Institute, Wako, has determined that a protein called cyclin-dependent kinase 5 (Cdk5) is required for neurons to develop their proper shape. …
2007 Aug 15Neurabin-I Is Phosphorylated by Cdk5: Implications for Neuronal Morphogenesis and Cortical MigrationCauseret F (index.php?option=com_comprofiler task=userProfile user=130), Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M. …
Further characterization of the Mib1-CDK5 interaction indicated that the N-terminal domain of Mib1 directly binds to the regulatory subunit p35 of the CDK5 complex. In cell culture, Mib1 induces the relocalization of p35/CDK5 without …
Led by Li-Huei Tsai, Picower Professor of Neuroscience at MIT, the scientists showed that inhibiting an enzyme called Cdk5 (a protein kinase) in the hippocampus, the centre in the brain that stores emotional memories, …
Li-Huei Tsai, Picower Professor of Neuroscience in the Department of Brain and Cognitive Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins) called Cdk5 facilitates the extinction of fear …
Memories are not always worth keeping…
What caught my eye, though, was the name Cdk5. I’d just last week read an article that mentioned it. Quick search of news archives and, yep, there it is: “Potential new treatment pathway for Parkinson’s”. Here’s an excerpt: …