“In our study, we employ mice to show that extinction of learned fear depends on counteracting components of a molecular pathway involving the protein kinase Cdk5. We found that Cdk5 activity prevents extinction, at least in part by …
What caught my eye, though, was the name Cdk5. I’d just last week read an article that mentioned it. Quick search of news archives and, yep, there it is: “Potential new treatment pathway for Parkinson’s”. Here’s an excerpt: …
Memories are not always worth keeping…
Li-Huei Tsai, Picower Professor of Neuroscience in the Department of Brain and Cognitive Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins) called Cdk5 facilitates the extinction of fear …
Led by Li-Huei Tsai, Picower Professor of Neuroscience at MIT, the scientists showed that inhibiting an enzyme called Cdk5 (a protein kinase) in the hippocampus, the centre in the brain that stores emotional memories, …
Further characterization of the Mib1-CDK5 interaction indicated that the N-terminal domain of Mib1 directly binds to the regulatory subunit p35 of the CDK5 complex. In cell culture, Mib1 induces the relocalization of p35/CDK5 without …
2007 Aug 15Neurabin-I Is Phosphorylated by Cdk5: Implications for Neuronal Morphogenesis and Cortical MigrationCauseret F (index.php?option=com_comprofiler task=userProfile user=130), Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M. …
A team of Japanese scientists led by Toshio Ohshima, at the RIKEN Brain Science Institute, Wako, has determined that a protein called cyclin-dependent kinase 5 (Cdk5) is required for neurons to develop their proper shape. …
Journal Of Cell Science; 07/01/2007 (AN 17591690) MEDLINE with Full Text.
Studies have shown that cyclin dependent kinase 5 (Cdk5) plays a key role in the apoptosis of mature neurons. Our recent findings suggest that Cdk5 functions in the nucleus to regulate apoptosis. We propose in the present application to …