Further characterization of the Mib1-CDK5 interaction indicated that the N-terminal domain of Mib1 directly binds to the regulatory subunit p35 of the CDK5 complex. In cell culture, Mib1 induces the relocalization of p35/CDK5 without …
Led by Li-Huei Tsai, Picower Professor of Neuroscience at MIT, the scientists showed that inhibiting an enzyme called Cdk5 (a protein kinase) in the hippocampus, the centre in the brain that stores emotional memories, …
Li-Huei Tsai, Picower Professor of Neuroscience in the Department of Brain and Cognitive Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins) called Cdk5 facilitates the extinction of fear …
Memories are not always worth keeping…
What caught my eye, though, was the name Cdk5. I’d just last week read an article that mentioned it. Quick search of news archives and, yep, there it is: “Potential new treatment pathway for Parkinson’s”. Here’s an excerpt: …
“In our study, we employ mice to show that extinction of learned fear depends on counteracting components of a molecular pathway involving the protein kinase Cdk5. We found that Cdk5 activity prevents extinction, at least in part by …
Led by Li-Huei Tsai, Picower Professor of Neuroscience at MIT, the scientists showed that inhibiting an enzyme called Cdk5 (a protein kinase) in the hippocampus, the centre in the brain that stores emotional memories, …
Li-Huei Tsai, Picower Professor of Neuroscience in the Department of Brain and Cognitive Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins) called Cdk5 facilitates the extinction of fear …
The p35/Cdk5 kinase is a neuron-specific Rac effector that …
Cyclin-dependent kinase 5 (Cdk5) and its neuron-specific regulator p35 are
essential for neuronal migration and for the laminar configuration of the
….
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9744280&dopt=Abstract>
CDK5
These data predict that the ability of cdk5 phosphorylation to protect
against htt cleavage, aggregation, and toxicity is compromised in cells
expressing …
<http://view.ncbi.nlm.nih.gov/gene/1020>