cdk5

Chemicon – Product #05-364 – Anti-cdk5, clone DC17
05-364 Qty: 200 g. Host: M IgG2a. Reacts with: Dr, H, M, R. Appl: IP, WB,
IC.
<http://www.chemicon.com/browse/productdetail.asp?ProductID=05-364>

Why GO sucks
By suicyte
This is no one-off phenomenon; other subfamilies contain “cytokines” as unlikely
as Cdk5 (a cell cycle kinase), erbin (binds to the cytoplasmic part of ErbB2 receptors)
ErbB2 (a receptor, part of a receptor dimer), PIK3R1 ( a PI-3 …
<http://suicyte.wordpress.com/2007/06/24/why-go-sucks/>
Suicyte Notes
<http://suicyte.wordpress.com>

Cognitive Enhancement Roundup
By director@ieet.org(director@ieet.org)
Turning off gene makes mice smarter Building on the 1999 “Doogie” mice research,
in which mice were made better maze-runners by manipulating their NR2B gene,
researchers have now made smarter mice by suppressing their Cdk5 gene, ….
<http://ieet.org/index.php/IEET/more/cogenh200706/#When:02:20:00Z>

Neuronal expression of muskelin in the rodent central nervous system.
By off(off)
Muskelin is expressed in adult brain and has been reported to bind the Cdk5
activator p39, which also facilitates the formation of functional synapses.
Since little is known about muskelin in neuronal tissues, we here analysed the …
<http://neurosciencemd.blogspot.com/2007/07/neuronal-expression-of-muskelin-in.html>

Tracing Parkinson’s Lethal Mechanism
Science Daily (press release) – USA
They also found evidence that calpains, in turn, activate a cellular switch
called Cdk5. The question, however, was how this abnormal activation
ultimately …
<http://www.sciencedaily.com/releases/2007/07/070705121900.htm>

Tracing Parkinson’s lethal mechanism
By FMS Global News
In their new studies, the researchers analyzed neurons to determine that Cdk5
regulates yet another enzyme called Prx2. This enzyme is known as a peroxidase
and acts to render harmless the chemically active reactive oxygen species that …
<http://globalhealthvision.wordpress.com/2007/07/05/tracing-parkinsons-lethal-mechanism/>
Global Health Vision

Scientists Track The Mechanism Of Parkinson’s Disease
AHN – USA
The researchers also found that treating neurons with
mitochondria-affecting toxin MPTP activates cellular switch called Cdk5 to
switch off Prx2. It also …
<http://www.allheadlinenews.com/articles/7007836626>

Newly found protein may be a key to Parkinson’s treatment
By Banshi Talukdar
They found a chain of events in which the toxin turns on a cellular switch,
called Cdk5, which then turns off Prx2. According to the researchers, the
findings suggest that strategies to modulate Prx2 activity may serve as beneficial …
<http://www.biopeer.com/biopeer/2007/07/new-neurotrophi.html>

MIT IDs mechanism behind fear
PhysOrg.com – Evergreen,VA,USA
Cdk5, paired with the protein p35, helps new brain cells, or neurons, form
and migrate to their correct positions during early brain development. ….
<http://www.physorg.com/news103727615.html>

MIT Finds Cure For Fear
Slashdot – USA
They did this by inhibiting a kinase, an enzyme that change proteins,
called Cdk5, which facilitates the extinction of fear learned in a
particular context. …
<http://science.slashdot.org/article.pl?sid=07/07/16/162246>

7.16.07
By support
In a report published online yesterday by the journal Nature Neuroscience,
Li-Huei Tsai and colleagues said an enzyme called cdk5 helps stem fears –
and, in mouse studies, can be manipulated to eliminate that fear. …
<http://www.lbnelert.com/?p=296>

PTSD lever
By SecureCare
“Researchers…show that inhibiting a kinase (kinases are enzymes that change
proteins) called Cdk5 facilitates the extinction of fear learned in a particular
context. Conversely, the learned fear persisted when the kinase’s activity was …
<http://www.baloney.com/archives/36>

One of fear’s governing mechanisms discovered
By Anxiety Insights
Li-Huei Tsai, Picower Professor of Neuroscience in the Massachusetts Institute
of Technology’s Department of Brain and Cognitive Sciences, and colleagues
show that inhibiting a kinase (enzymes that change proteins) named Cdk5 ….
<http://www.anxietyinsights.info/one_of_fears_governing_mechanisms_discovered.htm>

MIT Finds Cure For Fear
By ScuttleMonkey(pater@slashdot.org)
They did this by inhibiting a kinase, an enzyme that change proteins, called
Cdk5, which facilitates the extinction of fear learned in a particular context.”
Read more of this story at Slashdot.
<http://science.slashdot.org/article.pl?sid=07/07/16/162246&from=rss>

MIT finds cure for fear
By Joseph Smidt(Joseph Smidt)
Inhibiting a kinase, an enzyme that change proteins, called Cdk5 facilitates
the extinction of fear learned in a particular context, Li-Huei Tsai, Picower
Professor of Neuroscience in the Department of Brain and Cognitive Sciences, …
<http://theeternaluniverse.blogspot.com/2007/07/mit-finds-cure-for-fear.html>

How fear memories take hold
World Science – New York,NY,USA
Cdk5, a type of en-zyme, along with a pro-tein mol-e-cule p35, helps
new brain cells, or neu-rons, form and mi-grate to their cor-rect
po-si-tions dur-ing …
<http://www.world-science.net/othernews/070715_fear.htm>

Brain Target For Stress Disorder
By batgirl
Professor Li-Huei Tsai and colleagues in the Brain and Cognitive Sciences
Department at MIT looked at the effects of an enzyme called Cdk5 in the
brains of genetically engineered mice which had been given mild foot shocks. …
<http://www.ptsdforum.org/thread5040.html>

brain control
MIT biochemists have identified a molecular mechanism behind fear, and
successfully cured it in mice by inhibiting a kinase called Cdk5, according
to an article in Nature Neuroscience…. [KurzweilAI.net Accelerating Intelligence News]
<http://radio.weblogs.com/0101747/2007/07/17.html#a64>

/. does CDK5
By kinasepro
…. that describing a signalling pathway is the same as finding a cure :/ via:
Nature Neuroscience. A hippocampal Cdk5 pathway regulates extinction of
contextual fear. good luck getting that selective CDK5 inhbitor of yours ‘cross the b3.
<http://kinasepro.wordpress.com/2007/07/16/does-cdk5/>

MIT finds cure for fear
By pjwalker911
Inhibiting a kinase, an enzyme that change proteins, called Cdk5 facilitates
the extinction of fear learned in a particular context, Li-Huei Tsai, Picower
Professor of Neuroscience in the Department of Brain and Cognitive Sciences, …
<http://aftermathnews.wordpress.com/2007/07/17/mit-finds-cure-for-fear/>

Cdk5: the REAL Threat to the VIX
By Bill Luby(Bill Luby)
“In our study, we employ mice to show that extinction of learned fear depends
on counteracting components of a molecular pathway involving the protein
kinase Cdk5. We found that Cdk5 activity prevents extinction, at least in part by …
<http://vixandmore.blogspot.com/2007/07/cdk5-real-threat-to-vix.html>

‘Fear molecule’ may help in treating emotional disorders
Seattle Post Intelligencer – USA
In a report published online Sunday by the journal Nature Neuroscience,
Li-Huei Tsai and colleagues said an enzyme called cdk5 facilitates
extinction of …
<http://seattlepi.nwsource.com/national/323799_fearmolecule16.html>

Brain target for stress disorder
BBC News – UK
Professor Li-Huei Tsai and colleagues in the Brain and Cognitive Sciences
Department at MIT looked at the effects of an enzyme called Cdk5 in the
brains of …
<http://news.bbc.co.uk/1/hi/health/6897406.stm>

Drug to treat persistent fear now possible
ImediNews – Tbilisi,Georgia
MIT Professor Li-Huei Tsai and colleagues showed inhibiting a kinase called
Cdk5 facilitates the extinction of fear learned in a particular context.
….
<http://www.imedinews.ge/en/news_read/52004>

Scientist Work to Develop a Fear Pill
PsychCentral.com – Boston,MA,USA
Li-Huei Tsai and colleagues discovered inhibiting a kinase (kinases are
enzymes that change proteins) called Cdk5 facilitates the extinction of
fear learned …
<http://psychcentral.com/news/2007/07/16/scientist-work-to-develop-a-fear-pill/>

Study says you can control fear by inhibiting an enzyme
CBC British Columbia – Vancouver,British Columbia,Canada
Mice with increased levels of Cdk5 activity had more trouble “letting go”
of the memory of the foot shock and continued to freeze in fear. …
<http://www.cbc.ca/canada/british-columbia/story/2007/07/16/fearstudy.html>

I don’t want to be eaten by a lion
By Jon
Inhibiting a kinase, an enzyme that change proteins, called Cdk5 facilitates the extinction
of fear learned in a particular context, Li-Huei Tsai, Picower Professor of Neuroscience
in the Department of Brain and Cognitive Sciences, …
<http://www.blog.complainthub.com/?p=549>

Cure for fear?
By pr1ttyricky(pr1ttyricky)
The reverse was also true: in mice whose Cdk5 activity was inhibited, the bad memory
of the shocks disappeared when the mice learned that they no longer needed to fear the
environment where the foot shocks had once occurred.” …
<http://likealake.blogspot.com/2007/07/cure-for-fear.html>

Memories–Familiar Kinase, Cdk5, Limits Fear Extinction
Memories are not always worth keeping…
<http://www.alzforum.org/new/detail.asp?id=1626>

http://pressesc.com/01184528191_cure_for_fear
By jenmobbs
Inhibiting a kinase, an enzyme that change proteins, called Cdk5 facilitates the extinction of
fear learned in a particular context, Li-Huei Tsai, Picower Professor of Neuroscience in the
Department of Brain and Cognitive Sciences, …
<http://jenmobbs.wordpress.com/2007/07/20/httppressesccom01184528191_cure_for_fear/>

Fear Identified
By Erika(Erika)
Li-Huei Tsai, Picower Professor of Neuroscience in the Department of Brain and Cognitive
Sciences, and colleagues show that inhibiting a kinase (kinases are enzymes that change proteins)
called Cdk5 facilitates the extinction of fear …
<http://erika-klein.blogspot.com/2007_07_01_archive.html#4743149134222462279>

Why I can’t go to parties.
By JGordon
The stuff of nightmares: Just try and forget this, Cdk5 or no. (image by Mute on Flickr.com)
If I were to mouth off to a champion kickboxer at a party, and then get kickboxed into
stupefaction, a unique process would very likely be …
<http://www.smm.org/buzz/blog/why_i_can_t_go_to_parties>

The Science of Fear
By Daniel James Devine
“Remarkably, inhibiting Cdk5 facilitated extinction of learned fear in mice. This data points
to a promising therapeutic avenue to treat emotional disorders and raises hope for patients
suffering from post-traumatic stress disorder or …
<http://www.globelens.com/blog/2007/7/24/the-science-of-fear.html>

The Biochemical Mechanism of Fear
By Alex
Inhibiting a kinase, an enzyme that change proteins, called Cdk5 facilitates the extinction
of fear learned in a particular context, Li-Huei Tsai, Picower Professor of Neuroscience i
n the Department of Brain and Cognitive Sciences, …
<http://www.neatorama.com/2007/07/30/the-biochemical-mechanism-of-fear/>